Management of Large Focal Chondral and Osteochondral Defects in the Knee.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: S. L. S. reports personal fees from Joint Restoration Foundation, personal fees from Olympus, personal fees from Smith and Nephew, personal fees from Vericel, personal fees from Arthrex, personal fees from ConMed, personal fees from Flexion Therapeutics, personal fees from Vivorte, outside the submitted work.J. F. reports other from Active Implants, personal fees from Aesculap/B.Braun, from American Journal of Orthopedics, personal fees and other from Arthrex, Inc., personal fees from Biopoly, LLC, personal fees from Cartiheal, other from Cartilage, personal fees from Cook Biotech, Inc., other from Episurf, personal fees from Exactech, other from Fidia Pharma, other from JRF Ortho, personal fees from MedShape, Inc., personal fees and other from Moximed, Inc., other from Novartis, personal fees and other from Organogenesis, personal fees from Ortho Regenerative Tech, Inc., personal fees from Regentis, personal fees and other from Samumed, Inc., personal fees and other from Springer, personal fees and other from Thieme Medical Publishers, Inc., personal fees and other from Vericel, other from ZimmerBiomet, personal fees from ZKR Orthopedics, Inc., outside the submitted work. 15. Arch Orthop Trauma Surg. 2023 Jan;143(1):71-79. doi: 10.1007/s00402-021-03990-1. Epub 2021 Jun 14. Efficacy and safety of autologous chondrocyte implantation for osteochondral defects of the talus: a systematic review and meta-analysis. Hu M(#)(1), Li X(#)(1), Xu X(2). Author information: (1)Department of Orthopaedics, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, No, 999 Xiwang Road, Jiading District, Shanghai, 201801, China. (2)Department of Orthopaedics, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, No, 999 Xiwang Road, Jiading District, Shanghai, 201801, China. humu0912@163.com. (#)Contributed equally INTRODUCTION: Studies have reported various effects of autologous chondrocyte implantation (ACI) on osteochondral defects of the talus. Therefore, to assess the effectiveness of ACI for osteochondral defects of the talus, we used the meta-analytic approach. MATERIALS AND METHODS: Electronic databases PubMed, Embase, and the Cochrane Library were systematically searched to identify eligible studies from their inception until November 2020. The random-effects model was used to calculate the incidence of success rate and American Orthopaedic Foot and Ankle Society (AOFAS) score for patients after ACI treatment. Subgroup analyses were also conducted based on age, technique, indication, size, and follow-up duration. RESULTS: For the final meta-analysis, we selected 23 case series studies with a total of 458 patients with osteochondral defects of the talus. Overall, after ACI for patients with osteochondral defects of the talus, we noted that the incidence of success rate was 89% (95% confidence interval (95% CI) 85%-92%; P