High-Density Autologous Chondrocyte Implantation as Treatment for Ankle Osteochondral Defects.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. 15. Arch Orthop Trauma Surg. 2023 Jan;143(1):71-79. doi: 10.1007/s00402-021-03990-1. Epub 2021 Jun 14. Efficacy and safety of autologous chondrocyte implantation for osteochondral defects of the talus: a systematic review and meta-analysis. Hu M(#)(1), Li X(#)(1), Xu X(2). Author information: (1)Department of Orthopaedics, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, No, 999 Xiwang Road, Jiading District, Shanghai, 201801, China. (2)Department of Orthopaedics, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, No, 999 Xiwang Road, Jiading District, Shanghai, 201801, China. humu0912@163.com. (#)Contributed equally INTRODUCTION: Studies have reported various effects of autologous chondrocyte implantation (ACI) on osteochondral defects of the talus. Therefore, to assess the effectiveness of ACI for osteochondral defects of the talus, we used the meta-analytic approach. MATERIALS AND METHODS: Electronic databases PubMed, Embase, and the Cochrane Library were systematically searched to identify eligible studies from their inception until November 2020. The random-effects model was used to calculate the incidence of success rate and American Orthopaedic Foot and Ankle Society (AOFAS) score for patients after ACI treatment. Subgroup analyses were also conducted based on age, technique, indication, size, and follow-up duration. RESULTS: For the final meta-analysis, we selected 23 case series studies with a total of 458 patients with osteochondral defects of the talus. Overall, after ACI for patients with osteochondral defects of the talus, we noted that the incidence of success rate was 89% (95% confidence interval (95% CI) 85%-92%; P