"Periosteum: An imaging review".

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Abstract

Conflict of interest statement: No conflict of interest exists. 14. Semin Arthritis Rheum. 1988 Feb;17(3):156-62. doi: 10.1016/0049-0172(88)90017-0. Primary hypertrophic osteoarthropathy. Martínez-Lavín M(1), Pineda C, Valdez T, Cajigas JC, Weisman M, Gerber N, Steigler D. Author information: (1)Instituto Nacional de Cardiología Ignacio Chávez, Mexico, D.F. We describe seven patients with primary HOA and review 125 cases reported in the English, French, and German literature. The salient clinical features of primary HOA are: a bimodal distribution of disease onset with one peak during the first year of life and the other at age 15, a male predominance (nine to one), uncommon benign joint effusion, and a variety of skin abnormalities resulting from cutaneous hypertrophy or glandular dysfunction. We concluded that HOA is not a synovial disease. It is suggested that synovial effusions, when present, are perhaps a sympathetic reaction to the neighboring periostitis. Proposed diagnostic criteria for HOA, including digital clubbing and radiographic periostitis, appear 86% sensitive. The clinical features, age of onset, and sex distribution suggest that a genetically controlled growth promoting factor, different from growth hormone, plays a role in the pathogenesis of this syndrome. DOI: 10.1016/0049-0172(88)90017-0