Use of allograft bone matrix in clinical orthopedics.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: Y Li is one of the executive editors for Journal of Cellular Biochemistry (JCB). All other authors declare no COI or otherwise. The authors have no other competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript apart from those disclosed. 8. Braz J Med Biol Res. 2021 Jun 14;54(9):e11055. doi: 10.1590/1414-431X2021e11055. eCollection 2021. Biomaterials for bone regeneration: an orthopedic and dentistry overview. Girón J(1)(2), Kerstner E(3), Medeiros T(1)(2), Oliveira L(1), Machado GM(4), Malfatti CF(3), Pranke P(1)(2)(5). Author information: (1)Laboratório de Hematologia e Células Tronco, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil. (2)Programa de Pós-graduação em Fisiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil. (3)Programa de Pós-graduação em Engenharia de Minas, Metalúrgica e de Materiais, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil. (4)Programa de Gradução em Odontologia, Universidade Luterana do Brasil, Canoas, RS, Brasil. (5)Instituto de Pesquisa com Células Tronco, Porto Alegre, RS, Brasil. Because bone-associated diseases are increasing, a variety of tissue engineering approaches with bone regeneration purposes have been proposed over the last years. Bone tissue provides a number of important physiological and structural functions in the human body, being essential for hematopoietic maintenance and for providing support and protection of vital organs. Therefore, efforts to develop the ideal scaffold which is able to guide the bone regeneration processes is a relevant target for tissue engineering researchers. Several techniques have been used for scaffolding approaches, such as diverse types of biomaterials. On the other hand, metallic biomaterials are widely used as support devices in dentistry and orthopedics, constituting an important complement for the scaffolds. Hence, the aim of this review is to provide an overview of the degradable biomaterials and metal biomaterials proposed for bone regeneration in the orthopedic and dentistry fields in the last years. DOI: 10.1590/1414-431X2021e11055 PMCID: PMC8208772