The role of bone biopsy in the management of patients with renal osteodystrophy.

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Abstract

[Indexed for MEDLINE] 19. J Clin Densitom. 2018 Apr-Jun;21(2):157-162. doi: 10.1016/j.jocd.2017.03.001. Epub 2017 Apr 17. Obesity, Bariatric Surgery, and Vitamin D. Borges JLC(1), Miranda ISM(2), Sarquis MMS(3), Borba V(4), Maeda SS(5), Lazaretti-Castro M(5), Blinkey N(6). Author information: (1)Centro de Pesquisa Clínica do Brasil, Universidade Católica de Brasília, Brazil. Electronic address: jlborges@metabolismo.com.br. (2)Centro de Pesquisa Clínica do Brasil, Universidade Católica de Brasília, Brazil. (3)Universidade Federal de Minas Gerais, Brazil. (4)Disciplina de Endocrinologia, Universidade Federal do Paraná, Brazil. (5)Disciplina de Endocrinologia, Universidade Federal de Sao Paulo-Escola Paulista de Medicina, Brazil. (6)University of Wisconsin Medical School, USA. The high prevalence of obesity is a worldwide problem associated with multiple comorbidities, including cardiovascular diseases. Vitamin D deficiency with secondary hyperparathyroidism is common in obese individuals and can be aggravated after bariatric surgery. Moreover, there is no consensus on the optimal supplementation dose of vitamin D in postbariatric surgical patients. We present new data on the variability of 25(OH)D response to supplementation in postmenopausal obese women. It is important to recognize and treat vitamin D deficiency before bariatric surgery to avoid postoperative complications, such as metabolic bone disease with associated high fracture risk. The objective of this article is to discuss the bone metabolism consequences of vitamin D deficiency after bariatric surgery. Copyright © 2017 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved. DOI: 10.1016/j.jocd.2017.03.001