Revolutionizing bone tumor management: cutting-edge breakthroughs in limb-saving treatments.

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Abstract

[Indexed for MEDLINE] 15. Pediatr Blood Cancer. 2025 Apr;72 Suppl 2:e31374. doi: 10.1002/pbc.31374. Epub 2024 Oct 15. Contemporary surgical management of osteosarcoma and Ewing sarcoma. Callan AK(1), Alexander JH(2), Montgomery NI(3), Lindberg AW(4), Scharschmidt TJ(5), Binitie O(6). Author information: (1)Department of Orthopaedics, University of Texas Southwestern Medical Center, Dallas, Texas, USA. (2)Department of Orthopaedics, The Ohio State University, Columbus, Ohio, USA. (3)Department of Orthopaedics, Texas Children's Hospital, Houston, Texas, USA. (4)Department of Orthopaedics, Seattle Children's Hospital, Seattle, Washington, USA. (5)Department of Orthopaedics, Nationwide Children's Hospital, Columbus, Ohio, USA. (6)Department of Sarcoma, Moffitt Cancer Center, Tampa, Florida, USA. The incidence of malignant bone tumors has remained relatively stable over the past two decades between 8% and 9% per 1,000,000 in North America. Multidisciplinary treatment is paramount for optimal care combining surgical resection, chemotherapy, and rehabilitation. Surgical treatment aims for a negative margin resection of the sarcoma with a personalized reconstruction plan. Limb salvage surgery (LSS) is possible in the majority of cases; however, amputation (including rotationplasty) may be required or preferred. Reconstruction can be achieved utilizing endoprostheses, allograft, autograft, or a combination of these techniques. Emerging technologies such as 3D printing of implants and cutting guides, and intraoperative navigation have helped to improve options for LSS. © 2024 Wiley Periodicals LLC. DOI: 10.1002/pbc.31374