Limb Salvage and Reconstruction Options in Osteosarcoma.

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Abstract

[Indexed for MEDLINE] 4. Injury. 2017 Feb;48(2):206-213. doi: 10.1016/j.injury.2013.11.022. Epub 2013 Nov 28. Limb reconstruction after traumatic bone loss. Chimutengwende-Gordon M(1), Mbogo A(2), Khan W(3), Wilkes R(4). Author information: (1)Institute of Orthopaedics and Musculoskeletal Science, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore HA7 4LP, UK. Electronic address: mukai.cg@mac.com. (2)North Manchester General Hospital, Delaunays Road, Crumpsall, Manchester M8 5RB, UK. (3)Institute of Orthopaedics and Musculoskeletal Science, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore HA7 4LP, UK. (4)Limb Reconstruction Unit, Hope Hospital, Stott Lane, Salford, Lancashire M6 8HD, UK. A variety of options exist to reconstruct limbs following traumatic bone loss. The management of these injuries is challenging and often requires prolonged and potentially painful treatment. The Ilizarov technique of bone transport using circular external fixators is widely used for limb reconstruction of large bone defects. Other techniques include vascularised fibular grafting, the use of induced pseudosynovial membranes combined with cancellous autologous bone grafts and the use of autologous, allogeneic or synthetic bone grafts on their own for smaller defects. Future directions include further research on bone tissue engineering using stem cell therapy and growth factors such as bone morphogenetic proteins. The purpose of this Continuing Medical Education article is to describe the key limb reconstructive techniques that may be employed to treat traumatic bone loss. In particular, this article is intended to serve as a revision tool for those preparing for postgraduate examinations. Copyright © 2013 Elsevier Ltd. All rights reserved. DOI: 10.1016/j.injury.2013.11.022