Jersey Finger.

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Abstract

Conflict of interest statement: Disclosure: Mariano Abrego declares no relevant financial relationships with ineligible companies. Disclosure: Alan Shamrock declares no relevant financial relationships with ineligible companies. 3. Am J Surg Pathol. 2023 Jun 1;47(6):725-737. doi: 10.1097/PAS.0000000000002044. Epub 2023 Apr 27. Calcified Chondroid Mesenchymal Neoplasm: Exploring the Morphologic and Clinical Features of an Emergent Entity With a Series of 33 Cases. Kallen ME(1), Michal M(2), Meyer A(3), Suster DI(4), Olson NJ(5)(6), Charville GW(7), Perret R(8), Gross JM(9). Author information: (1)Department of Pathology, University of Maryland School of Medicine. (2)Biopticka Laboratory, Pilsen, Czech Republic. (3)Department of Pathology and Laboratory Medicine, University of Kansas School of Medicine, Kansas City, KS. (4)Department of Pathology, Immunology, and Laboratory Medicine, Rutgers New Jersey Medical School, Rutgers, NJ. (5)Physicians Laboratory. (6)University of South Dakota Sanford School of Medicine, Sioux Falls, SD. (7)Department of Pathology, Stanford Medicine, Stanford, CA. (8)Institut Bergonié / Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France. (9)Department of Pathology, Johns Hopkins Medicine, Baltimore, MD. Calcified chondroid mesenchymal neoplasm is a term proposed for tumors with a spectrum of morphologic features, including cartilage/chondroid matrix formation, that frequently harbor FN1 gene fusions. We report a series of 33 cases of putative calcified chondroid mesenchymal neoplasms, mostly referred for expert consultation out of concern for malignancy. Patients included 17 males and 16 females, with a mean age of 51.3 years. Anatomic locations include the hands and fingers, feet and toes, head and neck, and temporomandibular joint; 1 patient presented with multifocal disease. Radiologic review showed soft tissue masses with variable internal calcification, which occasionally scalloped bone but in all cases appeared indolent/benign. Tumors had a mean gross size of 2.1 cm and a homogenous rubbery to fibrous/gritty tan-white cut surface. Histology demonstrated multinodular architecture with a prominent chondroid matrix and increased cellularity towards the periphery of the nodules. The tumor cells were polygonal with eccentric nuclei and bland cytologic features and showed a variable amount of increased spindled / fibroblastic forms in the perinodular septa. The majority of cases had notable grungy and/or lacy calcifications. A subset of cases demonstrated at least focal areas of increased cellularity and osteoclast-like giant cells. Herein, we confirm the distinct morphologic and clinicopathologic features associated with this entity with the largest series to date, with a focus on practical diagnostic separation from similar chondroid neoplasms. Awareness of these features is critical in avoiding pitfalls, including a malignant diagnosis of chondrosarcoma. Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. DOI: 10.1097/PAS.0000000000002044