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PubMed Original Article Evidence Unclassified

Healthy Tendon Stem Cell-Derived Exosomes Promote Tendon-To-Bone Healing of Aged Chronic Rotator Cuff Tears by Breaking the Positive-Feedback Cross-Talk between Senescent Tendon Stem Cells and Macrophages through the Modulation of Macrophage Polarization.

Small (Weinheim an der Bergstrasse, Germany) | 2024 | Zhang X, Song W, Liu Y, Han K

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Source
PubMed
Type
Original Article
Evidence
Unclassified

Abstract

[Indexed for MEDLINE] 6. J Am Acad Orthop Surg. 2026 May 15;34(10):e1349-e1358. doi: 10.5435/JAAOS-D-25-00307. Epub 2026 Feb 6. Rotator Cuff Repair Augmentation. Huff SW(1), Haislup BD, Murthi AM. Author information: (1)From the Department of Orthopaedic Surgery, MedStar Union Memorial Hospital, Baltimore, MD. Rotator cuff repair (RCR) failure and retear remain a persistent problem and concern in shoulder surgery. Successful healing is paramount for long-term functional results. Failure of rotator cuff healing can be broadly separated into biologic and structural complications. Biologic issues include poor host variables such as healing ability and blood flow. Structural problems include tendon thinning and loss as well as poor time-zero fixation. Recently, commercial grafts or "patches" designed for rotator cuff augmentation have increased dramatically. Various grafts aim to enhance biology, provide structure, or both. In addition, grafts are designed to be placed either on-lay, over an RCR, or interpositional, at the bone-tendon interface. Graft may be allograft, xenograft, or fully synthetic. This article discusses the current RCR augmentation graft types and representative products currently available. Copyright © 2026 by the American Academy of Orthopaedic Surgeons. DOI: 10.5435/JAAOS-D-25-00307

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