Sarcomas of synovial origin in dogs: An updated review.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. 3. Pathol Res Pract. 2009;205(3):195-8. doi: 10.1016/j.prp.2008.10.003. Epub 2008 Nov 28. Ossifying synovial sarcoma. Hisaoka M(1), Matsuyama A, Shimajiri S, Akiba J, Kusano H, Hiraoka K, Shoda T, Hashimoto H. Author information: (1)Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan. hisaoka@med.uoeh-u.ac.jp Although intralesional calcification is a common finding of synovial sarcoma, ossification is an unusual phenomenon in such a soft tissue sarcoma. Here we report a case of ossifying synovial sarcoma arising in the back of a young adult man. Microscopically, the tumor was composed of spindle or oval cells together with foci of atypical polygonal cells in small nests or cord-like structures, displaying an epithelial appearance. In addition, extensive osteoid or woven bone formation was present in the tumor, resembling extraskeletal osteosarcoma. However, an SS18-SSX1 fusion gene transcript was detected by reverse transcription-polymerase chain reaction, supporting the diagnosis of biphasic synovial sarcoma. The osteogenic phenotype of the tumor cells was further demonstrated by an intense immunohistochemical expression of Runx2, a key transcription factor involved in the regulation of osteoblastic differentiation. The current case suggests the diagnostic utility of the molecular detection of a tumor type-specific fusion gene and expands the phenotypic plasticity of the soft tissue sarcoma of uncertain differentiation. DOI: 10.1016/j.prp.2008.10.003