Silicates in orthopedics and bone tissue engineering materials.

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Abstract

[Indexed for MEDLINE] 7. Regen Med. 2024 May 3;19(5):247-256. doi: 10.1080/17460751.2024.2353473. Epub 2024 Jul 19. Use of allograft bone matrix in clinical orthopedics. Manawar S(1), Myrick E(2), Awad P(2), Hung V(2), Hinton C(2), Kenter K(1), Bovid K(1), Li Y(1). Author information: (1)Department of Orthopedic Surgery, Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, MI 49008, USA. (2)Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, MI 49008, USA. Clinical orthopedics continuously aims to improve methods for bone formation. Clinical applications where bone formation is necessary include critical long bone defects in orthopedic trauma or tumor patients. Though some biomaterials combined with autologous stem cells significantly improve bone repair, critical-size damages are still challenged with the suitable implantation of biomaterials and donor cell survival. Extracellular matrix (ECM) is the fundamental structure in tissues that can nest and nourish resident cells as well as support specific functions of the tissue type. ECM also plays a role in cell signaling to promote bone growth, healing and turnover. In the last decade, the use of bone-derived ECMs or ECM-similar biomaterials have been widely investigated, including decellularized and demineralized bone ECM. In this article, we reviewed the current productions and applications of decellularized and demineralized bone matrices. We also introduce the current study of whole limb decellularization and recellularization. Plain Language Summary: [Box: see text]. DOI: 10.1080/17460751.2024.2353473 PMCID: PMC11321266