Paget's Disease of the Skull.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: The authors state that they have no Conflict of Interest (COI). 15. Curr Osteoporos Rep. 2016 Apr;14(2):39-42. doi: 10.1007/s11914-016-0303-6. Bone Quality in Paget's Disease of Bone. Singer FR(1)(2). Author information: (1)Endocrine/Bone Disease Program, John Wayne Cancer Institute, Providence Saint John's Health Center, Santa Monica, CA, USA. singer@jwci.org. (2)Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. singer@jwci.org. Paget's disease of bone is produced by a localized increase in osteoclastic and osteoblastic activity which can progress slowly to involve an entire bone if untreated. A common feature is enlarged bones which are deformed, particularly in weight-bearing regions of the skeleton such as the lower extremity. Pathologic fractures may be a consequence, and nonunion of femoral fractures is not uncommon. Analyses of bone biopsies from patients with Paget's disease indicate that there is a lower, heterogeneous degree of bone mineralization and a younger tissue age than that found in control bone. Pagetic bone also has less resistance to plastic deformation and a straighter crack path than control bone. DOI: 10.1007/s11914-016-0303-6