Paget's disease of bone.

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Abstract

[Indexed for MEDLINE] 6. Radiol Clin North Am. 2022 Jul;60(4):561-573. doi: 10.1016/j.rcl.2022.02.005. Imaging of Paget's Disease of Bone. Lombardi AF(1), Aihara AY(2), Fernandes ADRC(3), Cardoso FN(4). Author information: (1)Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA; Department of Radiology, University of California San Diego, San Diego, CA 92037, USA. Electronic address: alecio.lombardi@icloud.com. (2)Department of Diagnostic Imaging, Universidade Federal de São Paulo, São Paulo, SP 04024-000, Brazil; Diagnósticos da América (DASA), São Paulo, SP 05425-020, Brazil. (3)Department of Diagnostic Imaging, Universidade Federal de São Paulo, São Paulo, SP 04024-000, Brazil. (4)Department of Radiology, University of Miami Miller School of Medicine, Jackson Memorial Hospital, Miami, FL 33136, USA. Paget's disease is a metabolic bone disorder affecting the elderly and characterized by bone resorption followed by compensatory bone formation. Radiography is the imaging modality of choice for the diagnosis whereas bone scintigraphy helps stage the extent of the disease and assess response to treatment. MRI and CT are important imaging methods in the assessment of complications and surgical planning. Osteolytic lesions of Paget's first phase present with well-defined margins on radiographs, most commonly in the femur, pelvis, and skull. Cortical thickening, trabecular coarsening, bone marrow sclerosis, and deformities of long bones are present in the mixed- and late-sclerotic phases. Copyright © 2022 Elsevier Inc. All rights reserved. DOI: 10.1016/j.rcl.2022.02.005