Charcot Neuroarthropathy Advances: Understanding Pathogenesis and Medical and Surgical Management.

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Abstract

[Indexed for MEDLINE] 5. J Am Acad Orthop Surg. 2022 Nov 1;30(21):e1358-e1365. doi: 10.5435/JAAOS-D-22-00212. Epub 2022 Aug 25. Charcot Arthropathy of the Spine. Farrugia PR(1), Bednar D, Oitment C. Author information: (1)From the Department of Surgery, McMaster University, Hamilton, ON (Farrugia, Bednar, and Oitment), and the Division of Orthopedic Surgery, McMaster University, c/o St. Joseph's Hospital (Farrugia, Bednar, and Oitment). Charcot arthropathy of the spine (CSA), also known as spinal neuroarthropathy, is a progressive disease process in which the biomechanical elements of stability of the spine are compromised because of the loss of neuroprotection leading to joint destruction, deformity, and pain. Initially thought to be associated with infectious causes such as syphilis; however in the latter part of the century, Charcot arthropathy of the spine has become associated with traumatic spinal cord injury. Clinical diagnosis is challenging because of the delayed presentation of symptoms and concurrent differential diagnosis. Although radiological features can assist with diagnosis, the need for recognition and associated treatment is vital to limit the lifelong disability with the disease. The goals of treatment are to limit symptoms and provide spinal stabilization. Surgical treatment of these patients can be demanding, and alternative techniques of instrumentation are often required. Copyright © 2022 by the American Academy of Orthopaedic Surgeons. DOI: 10.5435/JAAOS-D-22-00212