Nonunion.

Journal and index pages often block iframe embedding. This reader keeps the evidence details in Orthonotes and leaves the source page one click away.

Abstract

[Indexed for MEDLINE] 8. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2024 Aug 25;53(4):450-459. doi: 10.3724/zdxbyxb-2023-0619. Advances on T cell immunity in bone remodeling and bone regeneration. [Article in Chinese, English; Abstract available in Chinese from the publisher] Hu W(1), Deng J(2), Su Z(2), Wang H(3), Lin S(4)(5). Author information: (1)Orthopedic Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, Guangdong Province, China. m15270155970@163.com. (2)Orthopedic Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, Guangdong Province, China. (3)Department of Orthopedics and Traumatology, Prince of Wales Hospital, Faculty of Medicine, The Chinese University of Hong Kong, Hongkong 999077, China. (4)Orthopedic Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, Guangdong Province, China. sienlin@cuhk.edu.hk. (5)Department of Orthopedics and Traumatology, Prince of Wales Hospital, Faculty of Medicine, The Chinese University of Hong Kong, Hongkong 999077, China. sienlin@cuhk.edu.hk. Bone remodeling and bone regeneration are essential for preserving skeletal integrity and maintaining mineral homeostasis. T cells, as key members of adaptive immunity, play a pivotal role in bone remodeling and bone regeneration by producing a range of cytokines and growth factors. In the physiological state, T cells are involved in the maintenance of bone homeostasis through interactions with mesenchymal stem cells, osteoblasts, and osteoclasts. In pathological states, T cells participate in the pathological process of different types of osteoporosis through interaction with estrogen, glucocorticoids, and parathyroid hormone. During fracture healing for post-injury repair, T cells play different roles during the inflammatory hematoma phase, the bone callus formation phase and the bone remodeling phase. Targeting T cells thus emerges as a potential strategy for regulating bone homeostasis. This article reviews the research progress on related mechanisms of T cells immunity involved in bone remodeling and bone regeneration, with a view to providing a scientific basis for targeting T cells to regulate bone remodeling and bone regeneration. Publisher: 骨重建和骨再生对于保持骨骼完整性和维持矿物质稳态至关重要。T淋巴细胞为适应性免疫的关键成员，通过产生一系列细胞因子和生长因子，在骨重建和骨再生过程中起着举足轻重的作用。在生理状态下，T淋巴细胞通过与间充质干细胞、成骨细胞、破骨细胞的交互作用参与骨稳态的维持；在病理状态下，T淋巴细胞通过与雌激素、糖皮质激素、甲状旁腺激素的协作参与不同类型骨质疏松的病理过程；在损伤后修复的骨折愈合过程中，T淋巴细胞在炎症血肿期、骨痂形成期和骨重建期发挥了不同的作用。因此，靶向T淋巴细胞成为调节骨稳态的潜在策略。本文综述了T细胞免疫参与骨重建和骨再生的研究进展及相关机制，以期为靶向T淋巴细胞调控骨重建和骨再生提供科学依据。. Bone remodeling and bone regeneration are essential for preserving skeletal integrity and maintaining mineral homeostasis. T cells, as key members of adaptive immunity, play a pivotal role in bone remodeling and bone regeneration by producing a range of cytokines and growth factors. In the physiological state, T cells are involved in the maintenance of bone homeostasis through interactions with mesenchymal stem cells, osteoblasts, and osteoclasts. In pathological states, T cells participate in the pathological process of different types of osteoporosis through interaction with estrogen, glucocorticoids, and parathyroid hormone. During fracture healing for post-injury repair, T cells play different roles during the inflammatory hematoma phase, the bone callus formation phase and the bone remodeling phase. Targeting T cells thus emerges as a potential strategy for regulating bone homeostasis. This article reviews the research progress on related mechanisms of T cells immunity involved in bone remodeling and bone regeneration, with a view to providing a scientific basis for targeting T cells to regulate bone remodeling and bone regeneration. DOI: 10.3724/zdxbyxb-2023-0619 PMCID: PMC11375490