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Evidence Search

Search reputable indexed orthopaedic literature from multiple scholarly sources, classify the evidence, and link papers directly to wiki topics and cases.

Sources: PubMed, Europe PMC, Crossref

Linking results to Wiki: Osteolysis & Wear in Arthroplasty
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Results are classified automatically from source metadata across PubMed, Europe PMC, and Crossref.
PubMed Crossref
PubMed Narrative Review Evidence Moderate

Periprosthetic osteolysis: Mechanisms and potential treatment strategies.

Cellular signalling | 2025 | Yao F, Bao Y, Meng Q, Chen Y

[Indexed for MEDLINE] Conflict of interest statement: Declaration of competing interest All authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest. 11. Acta Biomed. 2017 Jun 7;88(2S):98-111. doi: 10.23750/abm.v88i2-S.6520. Management of metaphyseal bone loss in revisi...

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PubMed Narrative Review Evidence Moderate

A review of wear debris in thumb base joint implants.

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie | 2024 | Mangan F, Spece H, Weiss AC, Ladd AL

[Indexed for MEDLINE] 7. J Knee Surg. 2015 Apr;28(2):139-44. doi: 10.1055/s-0034-1398375. Epub 2014 Dec 24. Wear and loosening in total knee arthroplasty: a quick review. Fraser JF(1), Werner S(2), Jacofsky DJ(3). Author information: (1)Department of Orthopedics, Banner Good Samaritan Hospital, Phoenix, Arizona. (2)Division of Adult Reconstruction, The CORE Institute, Center fo...

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PubMed Narrative Review Evidence Moderate

Hypersensitivity and lymphocyte activation after total hip arthroplasty.

Orthopadie (Heidelberg, Germany) | 2023 | Costa MD, Donner S, Bertrand J, Pop OL

[Indexed for MEDLINE] 15. Acta Orthop Belg. 1999 Jun;65(2):154-63. Femoral bone loss in total knee arthroplasty. A review. van Loon CJ(1), de Waal Malefijt MC, Buma P, Verdonschot N, Veth RP. Author information: (1)Department of Orthopedics, University Hospital Nijmegen, The Netherlands. Femoral bone loss in total knee arthroplasty (TKA) is a common feature and is mainly attrib...

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PubMed Narrative Review Evidence Moderate

Ortho Plastics The Adoption and Evolution of Polyethylene in Orthopedic Surgery.

Bulletin of the Hospital for Joint Disease (2013) | 2023 | Feder O, Lawrence KW, Driesman A, Schwarzkopf R

[Indexed for MEDLINE] 17. Clin Orthop Relat Res. 2007 Jul;460:240-52. doi: 10.1097/BLO.0b013e31804b4147. The biology of aseptic osteolysis. Holt G(1), Murnaghan C, Reilly J, Meek RM. Author information: (1)Department of Orthopaedic and Trauma Surgery, Southern General Hospital, Glasgow, Scotland, UK. Total hip arthroplasty is one of the most commonly performed and successful el...

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PubMed Narrative Review Evidence Moderate

Macrophage Polarization and the Osteoimmunology of Periprosthetic Osteolysis.

Current osteoporosis reports | 2022 | Goodman SB, Gibon E, Gallo J, Takagi M

[Indexed for MEDLINE] 13. J Am Acad Orthop Surg. 2007 Jan;15(1):53-64. doi: 10.5435/00124635-200701000-00006. Wear and osteolysis around total knee arthroplasty. Naudie DD(1), Ammeen DJ, Engh GA, Rorabeck CH. Author information: (1)Division of Orthopaedic Surgery, University of Western Ontario, London Health Sciences Centre, London, ON, Canada. Osteolysis induced by wear debris...

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PubMed Narrative Review Evidence Moderate

Reactive oxygen/nitrogen species (ROS/RNS) and oxidative stress in arthroplasty.

Journal of biomedical materials research. Part B, Applied biomaterials | 2020 | Hameister R, Kaur C, Dheen ST, Lohmann CH

[Indexed for MEDLINE] 19. JBJS Rev. 2016 Jul 5;4(7):e1. doi: 10.2106/JBJS.RVW.15.00081. Osteolysis Complicating Total Knee Arthroplasty. Gilbert TJ(1), Anoushiravani AA, Sayeed Z, Chambers MC, El-Othmani MM, Saleh KJ. Author information: (1)Division of Orthopaedics and Rehabilitation, Department of Surgery, Southern Illinois University School of Medicine, Springfield, Illinois....

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PubMed Narrative Review Evidence Moderate

Bone Defects in Revision Total Knee Arthroplasty and Management.

Orthopaedic surgery | 2019 | Lei PF, Hu RY, Hu YH

[Indexed for MEDLINE] 6. Eur J Orthop Surg Traumatol. 2024 Jan;34(1):251-269. doi: 10.1007/s00590-023-03622-x. Epub 2023 Jul 13. A review of wear debris in thumb base joint implants. Mangan F(1), Spece H(2)(3), Weiss AC(4), Ladd AL(5), Stockmans F(6), Kurtz SM(2)(3). Author information: (1)Loci Orthopaedics, Galway, Ireland. fiona@lociorthopaedics.com. (2)Drexel University, Phi...

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PubMed Narrative Review Evidence Moderate

Isolated Head and Liner Exchange in Revision Hip Arthroplasty.

The Journal of the American Academy of Orthopaedic Surgeons | 2017 | Walmsley DW, Waddell JP, Schemitsch EH

[Indexed for MEDLINE] 5. Orthop Surg. 2019 Feb;11(1):15-24. doi: 10.1111/os.12425. Epub 2019 Feb 27. Bone Defects in Revision Total Knee Arthroplasty and Management. Lei PF(1), Hu RY(2), Hu YH(1). Author information: (1)Department of Orthopaedic Surgery, Xiangya Hospital of Central South University, Changsha, China. (2)Department of Orthopaedic Surgery, Guizhou Provincial Peopl...

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PubMed Narrative Review Evidence Moderate

Management of metaphyseal bone loss in revision knee arthroplasty.

Acta bio-medica : Atenei Parmensis | 2017 | Mancuso F, Beltrame A, Colombo E, Miani E

[Indexed for MEDLINE] 12. Curr Osteoporos Rep. 2022 Feb;20(1):43-52. doi: 10.1007/s11914-022-00720-3. Epub 2022 Feb 8. Macrophage Polarization and the Osteoimmunology of Periprosthetic Osteolysis. Goodman SB(1), Gibon E(2), Gallo J(3), Takagi M(4). Author information: (1)Departments of Orthopaedic Surgery and Bioengineering, Stanford University, Stanford, CA, USA. goodbone@stan...

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PubMed Narrative Review Evidence Moderate

Wear and loosening in total knee arthroplasty: a quick review.

The journal of knee surgery | 2015 | Fraser JF, Werner S, Jacofsky DJ

[Indexed for MEDLINE] 8. Foot Ankle Int. 2021 Jan;42(1):55-61. doi: 10.1177/1071100720955155. Epub 2020 Sep 16. Bone Cysts and Osteolysis in Ankle Replacement. Najefi AA(1)(2), Ghani Y(3), Goldberg AJ(1)(4). Author information: (1)UCL Institute of Orthopaedics & Musculoskeletal Research, Royal National Orthopaedic Hospital, Stanmore, Middlesex, United Kingdom. (2)East & North H...

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PubMed Narrative Review Evidence Moderate

Emerging applications of proteomics in hip and knee arthroplasty.

Expert review of proteomics | 2014 | Cooper HJ

[Indexed for MEDLINE] 4. J Am Acad Orthop Surg. 2017 Apr;25(4):288-296. doi: 10.5435/JAAOS-D-15-00144. Isolated Head and Liner Exchange in Revision Hip Arthroplasty. Walmsley DW(1), Waddell JP, Schemitsch EH. Author information: (1)From the Division of Orthopaedic Surgery, Department of Surgery, Southlake Regional Health Centre, Newmarket, Ontario, Canada (Dr. Walmsley), the Di...

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PubMed Narrative Review Evidence Moderate

Current concepts in osteolysis.

The Journal of bone and joint surgery. British volume | 2012 | Ollivere B, Wimhurst JA, Clark IM, Donell ST

[Indexed for MEDLINE] 3. Expert Rev Proteomics. 2014 Feb;11(1):5-8. doi: 10.1586/14789450.2014.865522. Epub 2013 Dec 18. Emerging applications of proteomics in hip and knee arthroplasty. Cooper HJ(1). Author information: (1)Department of Orthopaedic Surgery, Adult Reconstructive Orthopaedic Surgery, Lenox Hill Hospital, 130 East 77th Street New York, NY 10075, USA jcooper02@gma...

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PubMed Original Article Evidence Unclassified

Osthole ameliorates wear particle-induced osteogenic impairment by mitigating endoplasmic reticulum stress via PERK signaling cascade.

Molecular medicine (Cambridge, Mass.) | 2024 | Yu X, Jiang J, Li C, Wang Y

[Indexed for MEDLINE] Conflict of interest statement: Declarations. Ethics approval and consent to participate: All experimental protocols were approved by the Ethical Committee of Nanjing Jinling Hospital, the Affiliated Hospital of Nanjing University Medical School. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. 10. C...

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PubMed Original Article Evidence Unclassified

Propionate and butyrate attenuate macrophage pyroptosis and osteoclastogenesis induced by CoCrMo alloy particles.

Military Medical Research | 2022 | Wu YL, Zhang CH, Teng Y, Pan Y

[Indexed for MEDLINE] Conflict of interest statement: The authors declare that they have no competing interests. 2. J Bone Joint Surg Br. 2012 Jan;94(1):10-5. doi: 10.1302/0301-620X.94B1.28047. Current concepts in osteolysis. Ollivere B(1), Wimhurst JA, Clark IM, Donell ST. Author information: (1)Norfolk & Norwich University Hospital, Colney Lane, Norwich NR4 7UY, UK. ben.olliv...

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PubMed Narrative Review Evidence Moderate

Wear and osteolysis around total knee arthroplasty.

The Journal of the American Academy of Orthopaedic Surgeons | 2007 | Naudie DD, Ammeen DJ, Engh GA, Rorabeck CH

[Indexed for MEDLINE] 14. Orthopadie (Heidelb). 2023 Mar;52(3):214-221. doi: 10.1007/s00132-023-04349-7. Epub 2023 Feb 23. Hypersensitivity and lymphocyte activation after total hip arthroplasty. [Article in English] Costa MD(1)(2), Donner S(3), Bertrand J(1), Pop OL(2), Lohmann CH(4). Author information: (1)Department of Orthopaedic Surgery, Otto-von-Guericke University, Leipz...

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PubMed Narrative Review Evidence Moderate

The biology of aseptic osteolysis.

Clinical orthopaedics and related research | 2007 | Holt G, Murnaghan C, Reilly J, Meek RM

[Indexed for MEDLINE] 18. J Biomed Mater Res B Appl Biomater. 2020 Jul;108(5):2073-2087. doi: 10.1002/jbm.b.34546. Epub 2020 Jan 2. Reactive oxygen/nitrogen species (ROS/RNS) and oxidative stress in arthroplasty. Hameister R(1), Kaur C(1), Dheen ST(1), Lohmann CH(2), Singh G(3). Author information: (1)Department of Anatomy, Yong Loo Lin School of Medicine, National University o...

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PubMed Original Article Evidence Unclassified

Bone Cysts and Osteolysis in Ankle Replacement.

Foot & ankle international | 2021 | Najefi AA, Ghani Y, Goldberg AJ

[Indexed for MEDLINE] 9. Mol Med. 2024 Dec 20;30(1):266. doi: 10.1186/s10020-024-01034-z. Osthole ameliorates wear particle-induced osteogenic impairment by mitigating endoplasmic reticulum stress via PERK signaling cascade. Yu X(#)(1), Jiang J(#)(2), Li C(#)(1), Wang Y(#)(1), Ren Z(2), Hu J(3), Yuan T(1), Wu Y(2), Wang D(4), Sun Z(1), Wu Q(5), Chen B(6), Fang P(1), Ding H(1),...

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PubMed Original Article Evidence Unclassified

Osteolysis Complicating Total Knee Arthroplasty.

JBJS reviews | 2016 | Gilbert TJ, Anoushiravani AA, Sayeed Z, Chambers MC

[Indexed for MEDLINE] 20. Radiographics. 2015 Sep-Oct;35(5):1483-501. doi: 10.1148/rg.2015140216. Epub 2015 Aug 21. MR Imaging of Knee Arthroplasty Implants. Fritz J(1), Lurie B(1), Potter HG(1). Author information: (1)From the Department of Radiology and Imaging, Hospital for Special Surgery, 535 E 70th St, New York, NY 10021. Primary total knee arthroplasty is a highly effect...

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Crossref Review Article Evidence Moderate

Review Article: Polyethylene Wear and Osteolysis in Total Hip Arthroplasty

Journal of Orthopaedic Surgery | 2001 | YH Zhu, KY Chiu, WM Tang

Polyethylene wear has been accepted as a major cause of osteolysis in total hip arthroplasty. Submicron particles, which are secondary to abrasive wear, migrate into the effective joint space and stimulate a foreign-body response resulting in bone loss which is mainly mediated by macrophages. Diagnosis depends on serial radiographic evaluation and frequent follow-up. Polyethyle...

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PubMed Narrative Review Evidence Moderate

Femoral bone loss in total knee arthroplasty. A review.

Acta orthopaedica Belgica | 1999 | van Loon CJ, de Waal Malefijt MC, Buma P, Verdonschot N

[Indexed for MEDLINE] 16. Bull Hosp Jt Dis (2013). 2023 Mar;81(1):78-83. Ortho Plastics The Adoption and Evolution of Polyethylene in Orthopedic Surgery. Feder O, Lawrence KW, Driesman A, Schwarzkopf R, Aggarwal V, Rozell J. Total joint arthroplasty relies on the use of biomaterials that are biologically inert and capable of forming wear-resistant articulating surfaces. Polyeth...

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Crossref Journal Article Evidence Unclassified

Orthopedic wear debris mediated inflammatory osteolysis is mediated in part by NALP3 inflammasome activation

Journal of Orthopaedic Research | 2013 | Lyndsey Burton, Daniel Paget, Nikolaus B. Binder, Krista Bohnert

AbstractActivation of myeloid cells by orthopedic particulate debris is a key event in the pathogenesis of periprosthetic osteolysis and implant loosening after total joint replacement (TJR). Several lines of evidence implicate NACHT, LRR, and PYD domains‐containing protein 3 (NALP3) inflammasome‐mediated production of interleukin 1 beta (IL‐1β) in the pathogenesis of clinical...

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