European journal of orthopaedic surgery & traumatology : orthopedie traumatologie | 2017 | Lesenský J, Mavrogenis AF, Igoumenou VG, Matejovsky Z Jr
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[Indexed for MEDLINE] 20. Injury. 2008 Apr;39(4):395-403. doi: 10.1016/j.injury.2007.07.018. Epub 2007 Dec 3. Pathological fractures in primary bone sarcomas. Papagelopoulos PJ(1), Mavrogenis AF, Savvidou OD, Benetos IS, Galanis EC, Soucacos PN. Author information: (1)First Department of Orthopaedics, Athens University Medical School, Athens, Greece. pjp@hol.gr Pathological fractures in patients with primary bone sarcomas should not be considered an absolute indication for amputation. Initial fracture management should include cast immobilisation or external fixation avoiding tumour-cell dissemination. The extent of fracture displacement and the type of fracture stabilisation may affect the outcome of patients with primary bone sarcomas presenting with pathological fractures. Patients with high-grade primary bone sarcomas should be treated by neo-adjuvant chemotherapy, and limb-salvage surgery. Pathological fractures in chemo-resistant primary bone sarcomas are a relative contraindication for limb salvage surgery. DOI: 10.1016/j.injury.2007.07.018
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