Bone Tumors: Primary Bone Cancers.

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Abstract

[Indexed for MEDLINE] 9. Histopathology. 2023 May;82(6):794-811. doi: 10.1111/his.14845. Epub 2022 Dec 16. Molecular and immunohistochemical testing of bone tumours: review and update. Kovacs SK(1), Manassaporn A(1), Nielsen GP(1), Hung YP(1). Author information: (1)Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Primary bone tumours can pose diagnostic problems due to their overlapping radiologic and histologic features. Given the recent advancement in our understanding of the biology of bone tumours, multiple immunohistochemical and molecular markers have been devised to aid in their diagnosis. This review provides brief updates on select bone tumours, including chondrosarcomas, benign chondrogenic tumours, osteosarcomas, benign osteogenic tumours, fibroosseous lesions, vascular tumours, osteoclastic giant cell-rich or cystic tumours, chordoma, adamantinoma, small round blue cell sarcomas, and others. We discuss their salient molecular features and novel immunohistochemical correlates, along with some tips to avoid common diagnostic pitfalls. © 2022 John Wiley & Sons Ltd. DOI: 10.1111/his.14845